Journal of Medical Sciences 2022-05-16T10:05:01+00:00 Prof . Dr . Ibrahim Abu Shanaf Open Journal Systems <p>Excellence in publishing scientific production, according to methodological standards and ethics of academic research. And contribute to the enrichment of all areas of science and specialized knowledge; accurately, honestly, and objective. And advance the level of scientific research in cooperation with the corresponding specialized scientific bodies and institutions, wherever they are. And keeping pace with scientific development and its techniques, to contribute to the development of the local community, and meet its knowledge needs. And increase scientific production, and publish theoretical research and applied studies, in order to achieve leadership at the national level. And provide opportunities for creativity and distinction for faculty and academics, by raising their academic degrees and professional competence. And work to make the scientific journal in the university a center of knowledge radiation at the local, national and international levels.</p> Cancer Testis Antigen (CTA) T21, as a Potential Diagnostic, Prognostic, and Immune-Therapeutic Targets for Malignant Tumours. 2022-05-10T09:07:36+00:00 Hoda M Tawel Yousef M Ali Hasen Amanda Miles <p>CTAs, are a family of tumour-specific shared antigens that represent promising targets for cancer immunotherapy, as well as, diagnostic and prognostic markers for tumour development.&nbsp;&nbsp;&nbsp; T21 is a novel antigen with little information known about its protein expression in malignant cells.&nbsp; This study was aimed at evaluating the expression of T21 antigen as a potential diagnostic and prognostic marker for diverse malignancies.&nbsp;&nbsp; Material and methods: IHC staining was applied using a mono-specific polyclonal antibody against T21 to diverse paraffin-embedded malignant tissue microarrays. The specificity of the staining was confirmed by the negativity of the isotype controls. The slides were imaged to visualise the positive T21 staining using an inverted light microscope (x 10) with digital net camera.&nbsp; IBM-SPSS statistic software, version 22, was used for descriptive and statistical data analysis.&nbsp; Results: T21 was expressed in a large percentage of the examined primary (84.9%) and metastatic (65%) tumour sections. T21 expression was evident in ccRCC, adenocarcinoma of small intestine, testicular tumours, adenocarcinoma of rectum, squamous cell carcinoma of oesophagus and astrocytoma. For metastatic tumours, the expression was remarkable in metastatic squamous cell carcinoma of unknown origin, metastatic breast carcinoma and metastatic thyroid carcinoma. There was no correlation the between T21 expression and tumour staging.&nbsp; Conclusion: T21 represents a potential target for cancer immunotherapy and vaccination.&nbsp; Overexpression of T21 antigen represents a useful diagnostic biomarker for cancer progression, but caution should be used when considering its potential for use as a prognostic marker. Further inclusive work focusing on the correlation of T21 expression and tumour staging is needed.</p> 2022-01-30T00:00:00+00:00 Copyright (c) 2022 Journal of Medical Sciences Head lice(Pediculus humanus capitis) infestation and the role of health education in limiting its spread among children at Primary-School in Misurata,Libya 2022-05-16T10:05:01+00:00 Naima Hussin Ftattet Fatema Ahmad Gloos <p>Pediculus humanus capitisis a worldwide scourge and children are more susceptible to infection than adults. Therefore, implementing health education programmes to control the spread of Head lice requires a great effort from teachers and parents. This study was conducted from November 2019 to February 2020 at some primary schools in Misurata city. The study community included 825 (male &amp; female) students between the ages of 7and 12. A first test was conducted to detect the prevalence of the infection with Pediculus humanus capitisis among students and the main influencing risk factors. Another test was conducted to achieve the effectiveness of health education in reducing infection . The results of this study revealed that the number of children with Pediculus humanus capitisis was 197 i.e. (23.9%) out of the 825 examined students. This percentage has decreased to (11.5%) following the intervention of health education programmes, with a statistical significance of (P&lt;0.05). Among the factors, the study showed two significant correlations(P&lt;0.05) . The first was between the infection rate and the participants’sex as the highest rate of infection was recorded among females at (31.1%). The other significant correlation was between the infection rate and the age, with the highest rate reaching (33.9%)among those aged 7years. It is concluded that the infection with Pediculus humanus capitisis has increased among primary-school students in Misurata when compared to other related studies. However, health awareness programmes at schools proved to have a beneficial effect in preventing and controlling the infection with Pediculus humanus capitisis.</p> 2022-05-16T00:00:00+00:00 Copyright (c) 2022 Journal of Medical Sciences Study of the prevalence of malaria parasite in migrant workers using rapid diagnostic test (RDTs) in Sebha, Libya. 2022-05-10T10:50:41+00:00 Naima I. Alhaddad Rugaia M. A. El-Salem <p>Malaria is a parasitic infection caused by a parasite of the Plasmodiidae family, Plasmodium that infects humans and is transmitted by female Anopheles mosquitoes. 229 million cases of malaria were recorded worldwide in 2019 and caused 409,000 deaths. Africa bears the brunt of this Infections Especially in sub-Saharan Africa, imported malaria cases among expatriates coming from endemic areas to malaria-free countries are a risk factor for these countries, so testing RDTs for the detection of the parasite in this category has been used as one of the prevention and control programs for the disease that requires intensification by Several parties related to disease control. This study was conducted during February and March of the year 2020 in the health care center in Sebha city. The study population included 135 people (males and females), their ages ranged from 15-67 years, who were subjected to a standardized questionnaire and examination of venous blood samples using the RDTs test.</p> <p>The results of our study showed that the prevalence rate of 14.8% (20) malaria cases out of the total number of cases, the age group 15-24 males had the highest incidence of Plasmodium falciparum malaria, and it was found through our study that there is a significant correlation between infection rate and educational level P=0.00 This is due to the lack of knowledge of ways to prevent the disease, and there was a significant correlation between infection rate and housing, P=0.02, which confirms the presence of a high prevalence of the vector in the affected villages. The aim of the study is to determine the extent of the malaria parasite prevalence and associated risk factors among expatriate workers in the city of Sebha using the Rapid Diagnostic Test (RDTs).</p> 2022-01-30T00:00:00+00:00 Copyright (c) 2022 Journal of Medical Sciences Maxillary crossbite correction with a rapid palatal expansion followed by a corrective orthodontic treatment 2022-05-16T09:06:41+00:00 Atef Omar Abosalah Eissa Ahmed Omar Abousalah Eassa Abdulsalam. E.E. Ibrahim <p>This case report presents the&nbsp; orthodontic treatment of a Libyan girl&nbsp; , aged 14 years 4 months with a Class lll&nbsp; malocclusion with severe transverse maxillary deficiency ( anterior sever crowding ,canines buccally eruption&nbsp; and posterior bilateral&nbsp; crossbite)(Figure 1) and correction using Haas expander and fixed orthodontic appliance(Figure2). The treatment goals were to correct the posterior crossbite and anterior crowding and restore the normality of the dentition and occlusion. In phase I, the patient was treated with a modified Haas-type palatal expander, which provided a clinically significant palatal expansion and increased the maxillary arch perimeter with favourable conditions for orthodontic treatment with fixed appliances in phase II. A removable wraparound type appliance and a bonded lingual canine-to-canine retainer were used as retention. Although the literature has reported a high rate of relapse after palatal expansion, after 2 years 9 months of post treatment follow-up, the occlusal result was stable and no skeletal reversals could be detected.</p> 2022-05-16T00:00:00+00:00 Copyright (c) 2022 Journal of Medical Sciences