Post Tonsillectomy Analgesia in Children with Paracetamol

Abduljalil Wafa; Ahmed Aburwais

doi:10.51984/e4sbt868

Authors

Abduljalil Wafa Department of Anesthesia, Tripoli Central Hospital, Tripoli, Libya
Ahmed Aburwais Department of Anesthesia, Tripoli Central Hospital, Tripoli, Libya

DOI:

https://doi.org/10.51984/e4sbt868

Keywords:

Paracetamol, Visual analogue scale, Tonsillectomy, Opioids, Nausea and vomiting

Abstract

Background: Pain, regardless of site can affect nearly every organ functions, and adversely influences postoperative morbidity and mortality. This study designed to compare the analgesic effect of paracetamol suppositories and intravenous formulas, theoretically delayed absorption and sub therapeutic plasma concentration can be avoided by giving drugs (Paracetamol) intravenously.

Patients and methods: Prospective study, was done on 120 children aged between 6-10 years (73 females and 47 males), ASA class 1 and 2. All were subject to elective tonsillectomy. Patients were classified randomly into 2 groups. Group (A): They received paracetamol intravenously 15 mg/kg after induction of anesthesia. Group B: They received paracetamol suppositories 30 mg/kg after induction of anesthesia. In all standard anaesthesia were used. Postoperatively pain scale using the visual analogue scale assessed for each patient, the incidence of using opioids and the incidence of nausea and vomiting were measured.

Results: Patients in group A were in slightly better analgesia in the first few hours postoperatively than those in group B and this supported by the statistical significant results (P<0.05) .Furthermore, The incidence of using rescue opioids and the incidence of nausea and vomiting are higher in group B than that in group A. However, they are not statistically significant (P>0.05).

Conclusion: Intravenous paracetamol is more effective in post tonsillectomy pain management in paediatric than the suppositories.

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References

Dahan A , Van Dorp E, Smith T, Yassen A. Morphine 6 glucuronide for postoperative pain relief. Eur. J. Pain. 2007 Sep.12.

Romej M, Voepel–Lewis T, Markel SI, Reynolds PI, Quinn P. St. Joseph Marcy Hospital, Ann Arbor, Michigan, USA. AANA 1996:64(6);535-40.

Romsing J, Hertel S, Harder A, Rasmussen M. Department of pharmaceutics, Royal Danish School of Pharmacy, Copenhagen, Denmark. Paediatric Anaesth. 1998:8(3);235-9.

Nettleton RT, Ransom TA, Abraham SL, Nelson CS, Olsen GD, Methadone induced respiratory depression in neonatal guinea pigs, Pediatric pulmonol 2007:42(12):1134-43.

Korpela R, Korvenoja P, Meretoja OA. Morphine sparing effect of acetaminophen in pediatric day case surgery. University of Helsinki, Anaesth. 2000:92(4);1202-3.

Card Well M, Siviter G, Smith A, M Non steroidal anti inflammatory drugs and perioperative bleeding in Paediatric tonsillectomy. Cochrane Database Syst. Rev. 2005:8;(2) CD003591.

Bremerich DH, Neidhart C, Heimann K, Kessler P, Behne M. Clinical Anesthesiology, Intensive care Medicine, and pain therapy, Johann Wolfgang Goethe universitat Frankfurt, Germany, Anaesth. Analog. 2001: 93(6):1626-7.