The Study of Antimicrobial Activity of Plant Extracts on H. Pylori bacteria


  • Mabrouka Abuzeid, Jody Winter, and Alsadig Mohammed Abdalla

الكلمات المفتاحية:

Helicobacter pylori, antibacterial activity, plant extracts.


Increasing resistance of H. pylori to common antibiotics is becoming an issue, and finding new treatment is crucial. Therefore, the current study was conducted to investigate the antimicrobial effect of extracts of six traditional medicine plants:  {Amla (Emblica officinalis), Terminalia chebula Retz., Irvingia gabonensis, Egusi (Citrullus colocynthis), Gentum africanum, Wase} on H. pylori Viability and toxicity. Results revealed that plant extracts have high inhibitory effect against H. pylori, which can be used as basis to treat H. Pylori infections. All the plant extracts (aqueous and the ethanolic extracts) revealed significantly high antimicrobial activity against H. pylori strains Tx30a and 60190. The inhibitory effects of plant extracts on the growth of Tx30a were significantly high with P value <0.0001 when compared with the controls. The most effective extract was the aqueous extract of Himej seeds. The multi comparison of Himej extract effects on H. pylori Tx30a with Egusi, Wase, and OKasi leaves extract showed P value<0.0001. The lowest effect on H. pylori Tx30a growth was shown by Okasi and Wase leaves extract. The antimicrobial effects of all plant extracts on H. pylori 60190 were also significantly high compared  with the controls (ethanol 100%, ethanol 70% and water) with p value <0.0001. The highest inhibitory effect on H. pylori 60190 was displayed by the aqueous extract of Himej seeds with p value <0.001 when compared with ethanolic extract of Amla and P value <0.0001 when its effect was compared with the control. Among the ethanolic extracts, the Amla fruit extract was the most effective against H. pylori 60190 with p value <0.0001 when compared with the control. The lowest antimicrobial activity against H. pylori 60190 was displayed by the ethanolic extracts of Egusi and Wase leaves with P value <0.001 followed by the ethanolic extract of Okasi leaves. 


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