TY - JOUR AU - Najem, Fatma I. E. Ali AU - Elgadi, Suliman A. AU - Taher, Ibrahim A. AU - Ali, Halema S. AU - Abusedra, Amina .S. PY - 2022/05/30 Y2 - 2024/03/28 TI - Genotyping of Hepatitis C Virus isolated from Libyan patients by line immune Probe Assay ( LiPA ) JF - Journal of Medical Sciences JA - joms VL - 17 IS - 1 SE - Articles DO - 10.51984/joms.v17i1.1919 UR - https://sebhau.edu.ly/journal/joms/article/view/1919 SP - 27-29 AB - <p>Chronic HCV infection contributed with the development of some diseases such as liver cirrhosis, cancer, and liver failure especially in HIV-positive patients during active antiretroviral therapy which may lead to death. This was the reason that genotyping has become a very important in routine diagnosis and management of chronic viral hepatitis infections. The purpose of this study was to see HCV genotypes among Libyan patients by LiPA technique, were a 75 blood samples were collected&nbsp; and&nbsp; processed at the laboratory of BIDIC (Benghazi Center of Infectious disease and Immunity) to perform the viral load and HCV genotyping. It was found that (60 %) of the collected samples belongs to HCV genotype 4, and (26.7 %) subtype 1a, while other subtypes 2a/2c, subtype 1b; Subtype&nbsp;&nbsp;&nbsp; 1a /1b; and genotype 2 all represented 5.3%; 5.3 %; 1.3 %; 1.3 % respectively. This concluded that HCVgenotypes in libya is distributed consuistently with Libyan neighboring countries. And the analysis of the 5′ UTR by LiPA with the INNO-LiPA HCV II kit can provide a quick, simple and reliable method for determination of the HCV genotype.</p> ER -