Study the Effect of Laser on some Natural Dyes, Pharmaceutical Drugs and Chemical Compounds

Due to the change of some drugs and natural products in the chemical components or chemical structure by exposing them to a laser beam or light, and the effect of heavy metals that may be present in them as a component in them, or as impurities in some medicines, colored dyes, and natural products. The presence of light and laser beam has been studied at time 40 minutes. There are chemical reactions or chemical bonds that may form between the metal ions of medicines such as ibuprofen, folic acid, librex, ranitidine, albendazole and the iron drug, except for Ca 2+ and Ni 2+ because they have the same λ max, and, the pigments found in carrots, red cabbage, beets, turmeric, and maringa , sage, excluding Ca 2+ and Ni 2+ due to having the same λ max, beet, folic acid, iporphine, and, turmeric had the most changes with metal ions, Cu, Ca, Ag, Ni, Fe, Cr, Cd, Pb, Zn and Mn ions after inducing the laser beam. The Ca 2+, and Ni 2+ ions are the most stable ions with all drugs, and pigments extracted from natural products than the rest of the other ions. Previous studies focused on studying the effect of the laser beam on chemical compounds, both separately. In this study, they focused on the effect of the laser beam on medicines and natural dyes, as well as what they may contain of heavy metals or impurities and the chemical changes that occur with them.


‫الكيميائية‬ ‫واملركبات‬ ‫واألدوية‬ ‫الطبيعية‬ ‫األصباغ‬ ‫بعض‬ ‫على‬ ‫الليزر‬ ‫تأثير‬ ‫دراسة‬
17 and drug efficacy and safety of the formulated products during manufacture, stock piling and uses, and some photochemical reactions happened in chemical compassion by light or laser light were studies. The fluorescence spectroscopy potential was determined for the characterization and comparison of different components of curcuminoids content in powders turmeric [1]. Nickel layer have a complex interaction between with a 4H-SiC substrate under irradiation of UV-Laser of the atomic inter-diffusion was investigated [2]. After π-π* excitation, the electronic dynamics of 4,5-dimethoxy-2-nitrobenzyl acetate was examined using a near-UV and pulse Laser [3]. The investigated of photochemical reactions of eight Bromophenols (BPs) and hydroxyl radical (OH) generated from NaNO2 using Laser flash photolysis (LFP) in aqueous solution [4]. The investigated the reaction between 2-chlorobiphenyl and N(III) photochemically in acidic nature by using co-linear LFP technique [5]. The studied of photochemical formation process of avobenzone (AB; 4-tert-butyl-4′-methoxy dibenzoyl methane) from 1,1-(4-tertbutybenzoyl) (4′-methoxybenzoyl) butane (Pr AB) by steady-state and Laser flash photolysis in solution [6]. Femtosecond Laser has better ability to change the size and shape of the material than nanosecond Laser then the size of the nanospheres decreased gradually due to many of photochemistry reactions at the surface of Ag nanospheres [7]. Converted Sm 3+ to Sm 2+ by the photoreduction and the formation of real defects are recorded at an irradiance less than the threshold for damage introduced by Laser [8]. The photoinduced electron-transfer reaction between pyrene and indole is reported by (LFP) [9]. A chemical reaction by Laser-driven have been expanded for thin-film microelectronics fabrication [10]. Investigated 10 -12 s and 10 -9 s dynamics of the ion pair formed by the electron transfer reaction between the triplet state benzophenone (3BP*) and 1,4-diazabicyclo [2.2.2] octane (DABCO) by Laserinduced photoconductivity measurement [11]. In an equivalent laminar methane / air flame, photo-fragmentation Laser-induced fluorescence (PFLIF) is for the first time perfect based on 10 -12 s Laser pulses for detection of (HO . ) radicals [12]. The observed IR photochemical reaction of C2F3Cl induced by transversely excited atmospheric CO2 (TEA CO2) Laser [13]. A stibazolium betaine (M) and (MH + ) was studied the dynamical behaviour of in their excited singlet states (S1) using 10 -12 s (LFP) [14]. In the pharmaceutical industry the photostability of drugs and drug products are studied by an integral part of the product evolution process [15]. Sensitized the photochemical produced reactive intermediates (PPRIs) by the pharmaceuticals in sunlit natural waters may induce photodegradation of coexisting compounds [16]. Phenothiazine (PTH) cation and neutral radical have been described by 10 -12 s (LFP) in acid and basic acetonitrile [17]. Dye degradation may initiate via direct photolysis (254 nm), photocatalysis (254 or 365 nm), and photosensitized conversions (visible) [18]. Studied of the photochemical reactions of ethyl erythrosine and ethyl eosin with diaryliodonium salts in acetonitrile [19]. Investigated of the photochemical properties of Fe (III) -Aspartate complex (Fe (III)-Asp) and its performance for the degradation of paracetamol (PC) in aqueous solution under UVA irradiation [20]. In this study, we show the extent to which light and laser beam are affected by some medicines and natural dyes that are found in plant foods that humans use through the change in the value of the wavelength of absorption of these substances, as well as their influence in the presence of some Heavy metal ions, as previous studies did not show the effect of laser beams on them, while they indicated the effect of laser on some chemical compounds or some natural pigments, both separately. 2. Experimental 2.1. Chemicals and Used equipment's 100 beakers of 100 ml capacity, filter paper, funnel, Graduated cylinder, cup, conical flasks -(He -Ne) Laser device, (Fig. 1), spectrophotometer, sensitive balance and standard 100 ml beaker 2.2. Preparation of solutions 100 ml of solution of 0.1 molar are prepared from the following materials: Cu SO4.5H2O (2.4968g), Ca (NO3)2. 4H2O (2.6313g) AgNO3 (1.9687g), NiCl2.6H2O (2.7371g), Fe SO4.7H2O (2.27g), Cr (NO3)3.9H2O (4.006g), Cd (NO3)3.4H2O (3.0848g), (CH3COO)2Pb 3H2O (3.7933g), ZnSO4.7H2O (1.815g) and 10/ Mn SO4. H2O (1.9602g)

Preparation of plant extracts
Grind 5 tablets of the following drugs and dissolved them in 100 ml of distilled water ibuprofen, folic acid, librax, rantidine, albendazol, and iron drug. Boil 5 g of the leaves of some plants or fruits for three minutes, in 100 ml distilled water such as carrots, cabbage, beets, turmeric, maringa, and sage about 100 ml of their extractions and juices with distilled water are filtered.

Effect of Laser beam
In Fig. 14. Show the effect of laser beam in copper metal complexes or copper metal ligands compounds which may be formed by observed the change of λ max. of copper metal complexes or Copper metal ligands compounds before effecting of Laser and after effecting of Laser. Meany of these compounds are changed due to change in bond formation specially ibuprofen folic acid beets and turmeric and others not changed. In Fig. 15. Show the effect of laser beam in Calcium metal complexes or Calcium metal ligands compounds may be formed by observed the change of λ max. of copper metal complexes or Copper metal ligands compounds before effecting of Laser and after effecting of Laser. Meany of these compounds are changed due to change in bond formation specially ibuprofen, folic acid, beets, sage and turmeric and others not changed. In Fig. 16. Show the effect of laser beam in silver metal complexes or silver metal ligands compounds may be formed by observed the change of λ max. of silver metal complexes or silver metal ligands compounds before effecting of Laser and after effecting of Laser, Meany of these compounds are changed due to change in bond formation specially ibuprofen, iron drug, beets, sage and turmeric and others not changed. In Fig. 17. Show the effect of Laser beam in Nickel metal complexes or Nickel metal ligands compounds may be formed by observed the change of λ max. of Nickel metal complexes or Nickel metal ligands compounds before effecting of Laser and after effecting of Laser. Meany of these compounds are changed due to change in bond formation specially ibuprofen, folic acid, beets, sage and turmeric and others not changed. In Fig. 18. Show the effect of laser beam in iron metal complexes or Iron metal ligands compounds may be formed by observed the change of λ max. of Iron metal complexes or Iron metal ligands compounds before effecting of Laser and after effecting of Laser. Meany of these compounds are changed due to change in bond formation specially ibuprofen, folic acid, beets, and turmeric and others not changed. In Fig. 19. Show the effect of laser in Chromium metal complexes or Chromium metal ligands compounds may be formed by observed the change of λ max. of Chromium metal complexes or Chromium metal ligands compounds before effecting of Laser and after effecting of Laser. Meany of these compounds are changed due to change in bond formation specially ibuprofen, folic acid, beets, and turmeric and others not changed. In Fig. 20. Show the effect of laser in Cadmium metal complexes or Cadmium metal ligands compounds may be formed by observed the change of λ max. of Cadmium metal complexes or Cadmium metal ligands compounds before effecting of Laser and after effecting of Laser. Meany of these compounds are changed due to change in bond formation specially ibuprofen, sage, beets, and turmeric and others not changed. In Fig. 21. Show the effect of Laser beam in Lead metal complexes or Lead metal ligands compounds may be formed by observed the change of λ max. of Lead metal complexes or Lead metal ligands compounds before effecting of Laser and after effecting of Laser. Meany of these compounds are changed due to change in bond formation specially Ibuprofen, iron drug, folic acid, sage, beets, and turmeric and others not changed. In Fig. 22. show the effect of laser beam in Zinc metal complexes or Zinc metal ligands compounds it may be formed by observed the change of λ max. of Zinc metal complexes or Zinc metal ligands compounds before effecting of Laser and after effecting of Laser. Meany of these compounds are changed due to change in bond formation specially ibuprofen, albendazol, sage, folic acid, sage, beets, and turmeric and others not changed. In Fig. 23 show the effect of Laser beam in Manganese metal complexes or Manganese metal ligands compounds may be formed by observed the change of λ max. of Manganese metal complexes or Manganese metal ligands compounds before effecting of laser and after effecting of Laser. Meany of these compounds are changed due to change in bond formation specially ibuprofen, sage, folic acid, beets, and Turmeric and others not changed.

Conclusion
The monitoring of some drugs like Ibuprofen, Folic acid, librax, rantidine, albendazol, and Iron. and natural products such as carrots, cabbage, beets, turmeric, maringa, and sage reacted with 10 metal ions, beet, folic acid, ibuprofen, and, turmeric had the most changes with metal ions, Cu, Ca, Ag, Ni, Fe, Cr, Cd, Pb, Zn, and Mn ions. The Ca 2+ , and Ni 2+ ions are the most stable ions with all drugs, and pigments extracted from natural products than the rest of the other ions.
We study the effect of Laser beam of the formations by measuring the absorbance's and λ max. wavelength λ max. of products. the change of λ max. inducts that bond formation of drugs and natural products with heavy metals may be formed which means that a photochemical reaction was happened and new compounds are formed by the effecting of Laser light. Recommendation: Drugs and natural dyes in foodstuffs such as carrots, beets, red cabbage and others should not be exposed for long time by light or laser beam, because this may change their chemical composition and may lose their nutritional value as well as drugs may lose their effectiveness, so we recommend further study to know and separate these new compounds which may result from exposure of these drugs and natural pigments to light and laser beams.