Spectrophotometric method for the determination of Colchicine in pure and pharmaceutical forms (A Kinetic Study)
Article Sidebar
-
Colchicines, , Kinetic, Oxidation, Permanganate, Spectrophotometer.
Abstract
Simple, rapid spectrophotometric method for the determination of colchicine in pure as well as in dosage form is described. This method was based on oxidation of colchicine by alkaline potassium permanganate at room temperature. Under the optimized reaction conditions, Beer’s law correlating the absorbance with colchicine concentration was obeyed in the range of 4-20 ?gml-1. The absorbance was measured at ?max 433, 524, and 610 nm. The calibration graph was linear over these concentrations. The limits of detection were 2.33, 5.83 and 2.86 µgml?¹, respectively. The stoichiometry of the reaction was studied. The method was successfully applied to the determination of colchicine in its pharmaceutical tablets, with high-quality accuracy and precisions.
Full text article
Authors
In a brief statement, the rights relate to the publication and distribution of research published in the journal of the University of Sebha where authors who have published their articles in the journal of the university of Sebha should how they can use or distribute their articles. They reserve all their rights to the published works, such as (but not limited to) the following rights:
- Copyright and other property rights related to the article, such as patent rights.
- Research published in the journal of the University of Sebha and used in its future works, including lectures and books, the right to reproduce articles for their own purposes, and the right to self-archive their articles.
- The right to enter a separate article, or for a non-exclusive distribution of their article with an acknowledgment of its initial publication in the journal of Sebha University.
Privacy Statement The names and e-mail addresses entered on the Sabha University Journal site will be used for the aforementioned purposes only and for which they were used.
