A study of relationship between renal biomarkers and D-dimer levels in patients with type 2 diabetes mellitus attending the Diabetes and Endocrinology Centre in Sebha city

Abstract

Background: Persistent hyperglycemia can lead to abnormal blood coagulation because of glycated hemoglobin and other clotting proteins. Changes in clotting factors and biochemical indicator levels may suggest an increased risk of blood clot formation, which can impact kidney function and result in vascular diseases. Objective: The main purpose of the study was to demonstrate the relationship between renal biomarkers and D-dimer levels in patients with type 2 diabetes mellitus attending the Diabetes and Endocrinology Centre in Sebha city. Materials and methods: Samples were collected from the diabetic patients attending the centre (50 patients, and 50 as a control), also kidney patients attending Sebha Medical centre were included (40 patient). Laboratory determination including Urea, creatinine, eGFR, FBS, HbA1C and D-dimer. Results: The results show that the mean of waist, hip, BMI, FBS, and HbA1C was significantly higher in the T2DM group as compared with other groups. mean of Urea, Creatinine and D-dimer was significantly higher in CKD group as compared other groups, while eGFR was decreased. No statistical difference was found between T2DM and control groups in urea, creatinine, and D-dimer. A positive correlation was found between (HbA1C, creatinine, and BMI) and D-dimer, while a negative correlation was demonstrated with eGFR. Conclusion: a positive significant association were found between D-dimer and both creatinine and HbA1C, but it was negatively correlated with eGFR.