Effect of Helicobacter Pylori Infection on Upper Air Way and Alimentary Tract Related Clinical Presentation in Gastroesophgeal Reflux Disease

Ebrahiem A. Bofares; Khalid M. Bofares

doi:10.51984/e4t0pk24

Authors

Ebrahiem A. Bofares Department of Medicine, Faculty of Medicine, Omar Almoukhtar University, Albayda, Libya
Khalid M. Bofares Otorhinolaryngology Department, Faculty of Medicine, Omar Almoukhtar University, Albayda, Libya

DOI:

https://doi.org/10.51984/e4t0pk24

Keywords:

GERD, Helicobacter pylori

Abstract

Back ground and objectives: Gastro esophageal reflux disease (GERD) is believed to be important contributing factor in many disorders of upper respiratory and alimentary tracts namely rhinosinusitis nasal polyps, adenoid enlargement, chronic tonsillitis, chronic pharyngitis, chronic esophagitis, esophageal strictures, chronic laryngitis, otitis media, and chronic chest infections. It has been reported that GERD and Helicobacter pylori infection may be interrelated phenomena. Although there are many theories tried to explain the pathogenesis of GERD but still Helicobacter pylori based theory is considered as strong theory via which the GERD pathophysiological mechanism factor can be presented. The successful eradication of Helicobacter pylori infection was shown to be significantly related to improvement of the symptomatology in patients with chronic upper air way and alimentary tract related disorders. Therefore this study was conducted prospectively to confirm this concept.

Materials and methods: Two hundred and thirty five patients aged 5-85 years of different GERD stages presented with varities of upper air way and alimentary tracts related clinical presentations underwent serological examination for Helicobacter pylori before and after eradicative medication of infection.

Results: Two hundred and eight patients (89%) of the total number showed positive Helicobacter pylori and 203 cases (98%) were improved after medical eradicative course against Helicobacter pylori. On the other hand only 27 patients (11%) with either upper air way or alimentary tract related disorders were found to have negative Helicobacter pylori results.

Conclusion: Helicobacter pylori infection, as a predisposing factor in the pathogenesis of GERD plays a significant role in the incidence of the upper air way as well as upper alimentary tract related disorders, and the proper control of Helicobacter colonization will be positively reflected on the clinical status.

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