Prevalence of hemoglobinopathies in Ghat-South Libya
Article Sidebar
-
Hemoglobinpathies, sickle cell, -thalassemia, HPLC Ghat.
Abstract
Hemoglobinopathies are group of genetic disorders of haemoglobin in which there is a quantitative or qualitative abnormal production or structure of haemoglobin molecule. These hereditary disorders are major public health problem in many parts of the world including Libya. This study was designed to determine the prevalence of Hemoglobinopathies in Ghat Region - South of Libya. In this prospective cross-sectional study, 5 ml of venous blood was collected from 1912 (1176 females and 736 males), aged between 5- 90 years (20.08± 12.52). The hematological picture of all samples were evaluated using SYSMEX KX- 21 N Automated Hematology Analyzer , and all sample were screened for hemoglobinopathies using Sickling test, Solubility test and High Performance Liquid Chromatography (HPLC).The result showed that the overall prevalence of the HbS in Ghat region was 5.75% (110 samples out of 1912 samples), in which there was 0.57% with HbSS and 5.18% with HbAS, no other abnormal hemoglobin's were found in the study.
The result of HPLC study show that the most common hemoglobin in the sickle cell trait sample was HbA (range 56.9 – 70.4%), followed by HbS with range between 24.2 – 37.2%, while the range of HbA2 was 1.0 – 3.9% and HbF was 0.4 – 8.7%. The most common hemoglobin in sickle cells disease was HbS with range 62.7 – 69% followed by HbA with range between 27.0 – 33%, HbA2 with range between 1.1 – 1.3% and HbF with range between 0.9 – 2.0%, and there was no any case of sickle cell disease in the first age group.
Full text article
Authors
This work is licensed under a Creative Commons Attribution 4.0 International License.
In a brief statement, the rights relate to the publication and distribution of research published in the journal of the University of Sebha where authors who have published their articles in the journal of the university of Sebha should how they can use or distribute their articles. They reserve all their rights to the published works, such as (but not limited to) the following rights:
- Copyright and other property rights related to the article, such as patent rights.
- Research published in the journal of the University of Sebha and used in its future works, including lectures and books, the right to reproduce articles for their own purposes, and the right to self-archive their articles.
- The right to enter a separate article, or for a non-exclusive distribution of their article with an acknowledgment of its initial publication in the journal of Sebha University.
Privacy Statement The names and e-mail addresses entered on the Sabha University Journal site will be used for the aforementioned purposes only and for which they were used.
