Evaluation of Genotoxicity of Acetone Extract of Dodonaea viscose L. Plant Leaves on the Mitosis of Root Tips of Allium cepa
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Allium cepa , Chromosomal Aberrations , Cytotoxic, Dodonaea viscosa L , Extract.
Abstract
This study aims to evaluate the genotoxicity of acetone extract of Dodonaea viscosa L. plant leaves on the mitosis in root tips of Allium cepa using three concentrations (6, 0.6, and 0.06) mg/ml, for 24 hrs of treatment. depending on some cytogenetic analysis such as mitotic index, phase index and chromosomal aberration. The results showed that treatment with all extract concentrations resulted in a decrease in the percentage of mitotic index , this percentage decrease to less than 50% with the treatment of 6 mg/ml compared to the control group , also the results showed that the extract treatment resulted in different chromosomal aberrations especially when treated with concentration 0.6 mg/ml which showed a significant increase at P <0.05 in the mean values ??of the total number of chromosomal aberrations in all stages of mitosis compared to the control group and concentrations of (6, 0.06) mg/ml. The chromosomal aberrations observed in this study were represented in fragments, stickiness chromosomes, lagging chromosomes, chromosomal bridges, breaks, granulated prophase, disturbed chromosomes and clumped chromosomes. We concluded from this study that Dodonaea viscosa L. , which is used in many medical fields has genotoxic effect as the results of this study showed that the treatment with acetone extract of this plant led to inhibition of mitosis in the root tips of Alium cepa and induced of many chromosomal aberrations at all stages of mitosis.
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