Study on Hematological Morphological and Biochemical Changes in Patients with Chronic Kidney Failure
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Chronic Kidney Disease, Complete Blood Count, Erythrocyte Morphology, Hematological Changes, Kidney Failure
Abstract
Chronic kidney failure is a worldwide health problem, affecting millions of people. It is a syndrome characterized by progressive and irreversible deterioration of renal function due to slow destruction of renal parenchyma, eventually terminating in death when sufficient numbers of nephrons have been damaged. This study was carried out to evaluate the hematological, morphological, and biochemical changes in kidney failure patients and compare them with a normal group. 100 samples were collected from Sebha Medical Centre. Complete blood counts and kidney function (urea and creatinine) were measured. The results of this study indicate that there were significantly decreased values of Hg, RBC, PCV, and RDW (p=0.0001) in chronic kidney failure patients when compared with the normal group. On the other hand, there was no significant difference in the values of MCV, MCH, MCHC, WBC, and Plt observed in kidney failure patients when compared to the normal group. In addition, the kidney failure group showed significantly increased levels of urea and creatinine p=0.0001 when compared to the normal group alone. The morphological changes of erythrocytes were observed under a light microscope. The kidney failure group showed morphological changes in the form of echinocytes, target cells, poikilocytosis, and elliptocytes. In conclusion, based on the above finding, these results indicate that the complications of chronic kidney failure may lead to hematological, morphological, and biochemical changes of erythrocytes.
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