Study on hematological morphological and biochemical changes in patients with chronic kidney failure
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Chronic kidney disease, Complete blood count, Erythrocyte morphology, Hematological changes, Kidney failure.
Abstract
Chronic kidney failure is a worldwide health problem, affecting millions of people, it is a syndrome characterized by progressive and irreversible deterioration of renal function due to slow destruction of renal parenchyma, eventually terminating in death when sufficient numbers of nephrons have been damaged. This study was carried out to evaluate the hematological, morphological and biochemical changes in kidney failure patient and compared with normal group. 100 samples were collected from Sebha Medical Centre. Complete blood counts, kidney function (urea and creatinine) were measured. The results of this study indicate that there were significantly decreased values of Hg, RBC, PCV, RDW (p=0.0001) in chronic kidney failure patient when compared with normal group, On the other hand there no significantly different in the values of MCV, MCH, MCHC, WBC, Plt were observed in kidney failure patient when compared to normal group. In addition, kidney failure group showed significantly increased levels of urea and creatinine p=0.0001 when compared to normal group alone. The morphological changes of erythrocytes were observed under a light microscope. Kidney failure group showed morphological changes in the form of echinocytes, Target cell, Poikilocytosis, elliptocytes. In conclusion, based on the above finding these results indicate that the complications of chronic kidney failure may lead to hematological, morphological and biochemical changes of erythrocyte.
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