Synthesis, Spectroscopic, Thermal Studies of Palladium(II) Complex of SNO Donor Schiff Base and Their DNA Cleavage Activity
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5-Chloro Isatin, 4-Methyl-3-Thiosemicarbazid, Square-Planar, Supercoiled pBR322
Abstract
Palladium (II) complex of Schiff base ligand derived from the reaction of 5-chloro isatin with 4-methyl-3-thiosemicarbazid has been synthesized in absolute ethanol. The structures of the isolated solid compounds have been characterized by elemental analysis and spectral (FT-IR and UV-vis) measurements. In addition, the synthesized compounds were subjected to the thermal study (TGA). The Schiff base ligand was further characterized by 1H-NMR spectroscopy. It has been found that the Schiff base ligand behaves as a bidentate ligand, forming a chelate 1:1 (metal:ligand). Square-planar geometry was suggested for the Pd(II) chelate. The synthesized compounds were tested against supercoiled pBR322 DNA. These compounds have been found to promote the cleavage of plasmid DNA pBR322 in the presence of H₂O₂..
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