Co-expression of Extended Spectrum ?-lactamase (ESBL) and AmpC ?-lactamase among Pseudomonas aeruginosa clinical isolates in sebha medical center
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AmpC β-lactamase enzymes, ESBL, MDR, and Pseudomonas spp.
Abstract
The aim of this study was to assess the resistance rate and pattern in Pseudomonas aeruginosa isolates recovered from patients admitted to Sebha medical center, Libya. P. aeruginosa is a known opportunistic pathogen which has become of great concern due to its high resistance to a wide range of antibiotics. This study was performed to evaluate the frequency of the Extended spectrum ?-lactamase (ESBL) and AmpC ?-lactamase enzymes in P. aeruginosa clinical isolates. Thirty-one non-repetitive clinical samples of P. aeruginosa were studied for their antibiotic sensitivity, ESBL and AmpC ?-lactamase production. The phenotypic screening test for antibiotic showed 100% resistance to Penicillin, Ampicillin, Amoxicillin and ?-lactamase inhibitor. The majority of the isolates were resistant to third generation cephalosporins (Ceftriaxone and Cefotaxime). In this study 29% of all isolates were resistant to gentamicin and 19% were resistant to ciprofloxacin. While all isolates were sensitive to Imipenem, 97% were resistant to Nalidixic acid and Fucidic acid. The resistance to Tetracyclins and Chloramphenicol was 94% and 90% respectively. All isolates exhibited ESBL phenotype but only 48% (15/31) confirmed as Ampc ?-lactamase enzymes producers using Boric acid and EDTA.
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