The frequency of ABO and Rhesus blood groups phenotypes, genotypes from Sebha city of Libya
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ABO blood-group system, Alleles frequencies, GenotypeFrequencies.
Abstract
The frequency of ABO and Rhesus blood groups vary geographically, ethnically and from one population to another. Some variations may even occur within one ethnic group and within one small country. This study was conducted to determine the frequency of ABO and Rhesus blood groups phenotypes, genotypes and alleles in Sebha city.A total of 527 samples were randomly collected and tested for ABO and Rhesus blood groups antigens using open slide methods. The frequencies of ABO and Rhesus blood groups phenotypes were expressed in percentages and the Hardy-Weinberg Law was used to determine allele and genotype frequencies.Results: Blood group (O) is the most frequented group (42%) of the totally, followed by group (A) (28%) and group B (23%). Least prevalent blood group was AB (7%). Rh D positive prevalence was 81.7% and 18.2% persons were Rh negative. The allele frequencies of IO, IA, and IB in the total sample were found to be, 0.649, 0.194, and 0.160 respectively. The order of ABO blood group allele frequencies was IO > IA > IB in the overall samples. ConclusionIn present study blood group O was the commonest followed by group A. the order of the frequencies of ABO blood group alleles is IO > IA > IB. Therefore, the findings of this study can be used as a baseline for the genetic diversity of the study area as a reference for Libyan ABO blood group phenotypes and genotypes studies.
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