Chemoprotective activity of 3-indolylmethyl glucosinolate on induced gastric mucosal injury in male rats
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Histochemical, Gastroprotective, Aspirin, 3-Indolylmethyl glucosinolate, Rats.
Abstract
Mucosal damage in stomach therapy faces a major drawback in modern days due to the unpredictable side effects of the long-term uses of commercially available drugs. The aim of the present investigation study is to evaluate the chemoprotective activities of 3-indolylmethyl glucosinolate against aspirin-induced gastric mucosal damage in male albino rats. Rats were divided into two large groups, control group and ulcerated group. Aspirin (500 mg/kg/body weight for a week), and followed by the beginning of different experimental regimens for a total experimental duration of one month. Results of the present work showed that, the groups were treated with 3-indolylmethyl glucosinolate possessed protective activity by an increase the mucus level, protein granules and a great number of proliferation cells in the stomach. So this study suggests that, 3-indolylmethyl glucosinolate possesses significant gastroprotective and antioxidant activities against aspirin-induced gastric ulcer in male albino rats.
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