Effect Of Boiled Peganum Harmala Seeds on the Embryos of Experimental Laboratory Mice
Article Sidebar
-
Peganum Harmala, Pregnant Mice, Embryos, Teratogeni
Abstract
This study was conducted on 120 pregnants Swiss albino mice, their ages 3-4 months and their body weights were 25-30 gm. The aim of this study is to detect the effect of boiled harmal seeds infusion on the embryos, particularly during the period of organogenesis. The pregnants were divided into 6 groups. The pregnants of the first group were given distilled water only and considered to be a control group, while the rest groups were orally given the doses 0.5, 1, 2, 4 and 6 g / kg of body weight daily, during the days 7-12 of pregnancy. The results show that the boiled harmal seeds infusion has poison and malformation effects on embryos whose mothers were given doses 1,2,4 and 6 g/kg of body weight, while those of mothers given 0.5 g /kg of body weight appeared normal as those of control group. All of those observed deformative may be occurred due to the timing of doses given, where the period of organogenesis is considered to be the most critical period of pregnancy, so we advise the pregnants to avoid taking any parts of this plant especially during the early of pregnancy
Full text article
References
[1]- القاضي ، ع ؛ موسى ، ع . ا. 1999. استعمالات بعض النباتات في الطب الشعبي الليبي. الطبعة الثالثة. الجزء الثالث. دار الكتب الوطنية. بنغازي.
[2]- بولس ، ل. 1970 . الأعشاب الطبية في ليبيا. مطبعة. 16 / الشرق الأوسط للتصدير ش . م 70 7174 لبنان.
[3]- ساسي، س. م. 2008 . تأثير مغلي بذور نبات الحرمل على أمهات فئ ا رن التجارب المعملية وأجنتها. رسالة ماجستير، جامعة طرابلس، طرابلس، ليبيا.
[4]- ساسي، س. م ؛ داود ، د. س؛ ساسي، ن. م. 2013 تأثير مغلي بذور نبات الحرمل على أمهات فئ ا رن التجارب. مجلة العلوم الاساسية والتطبيقية. ط ا ربلس. المجلد 19 العدد 2. ص 33-51
[5]- Bailey, M. E. 1986. Principal poisonous plants in the South western United States. In : Howard JL. Current Veterinary Therapy, food Animal Practice. Philadelphia, P 413.
[6]- El-Bahri, L. and Chemli, R. 1991. Peganum harmala L: A poisonous Plants of North Africa. Vet. Hum. Toxicol., 33 : 276-277
[7]- Emboden, W. A. 1979. " Narcotic plants" New York, MC millian, p125.
[8]- Joghataei, M. T and Mahdizadeh, M. 2003. Study teratogenic effect of Peganum harmal plant on skeletal system and mice embryo growth rate using Alizarin red. Journal Iranian anatomical science, 1(1): 35 – 39.
[9]- Kamel, S.;Ibrahim, T.; Afifi, A. and Hamza, S. 1970. Major alkaloid Constituents of the Egyptian plant, Peganum harmala. UARJ. Vet. Sci, 7 : 71- 86.
[10]- Lamchouri, F.; Settaf, A.; Cherrah, Y.; Elhamid, M.;Tligui, N. S.; Lyoussi, B. and Hassar, M. 2002. Experimental toxicity of Peganum harmala Seeds. Ann. Pharm. Fr., 60: 123 - 129.
[11]- Li, Y.; Liang, F.; Jiang, W.; et al. 2007. DH334, a beta – carboline anti- cancer drug, inhibits the CDK activity of budding yeast. Cancer Biol Ther. 6 (8): 1193 - 9
[12]- Mahmoudian, M.; Jalil pour, H. and Salehian, P. 2002. Toxicity of Peganum harmala . Review and case report. Iranian J. Pharmacol. Therapeutic., 1: 1- 4.
[13]- Marwat, S. K and Rehman, F. 2011. Nuts and seeds in health and disease prevention. London: Academic Press: 585 – 599.
[14]- Mina, C. N;. Mohammad, H. F. and Gholamreza, A. 2015. Medicinal Properties of Peganum harmal L. in traditional Iranian medicine and modern phytotheraps a review. J Tradit Chin Med. 35(1): 104 – 109.
[15]- Moloudizargari, M.; Mikaili, P.; Aghajanshakeri, S. H.; Asghari, M. H. and Shayegh, J. 2013. Pharmacolgical and therapeutic effects of Peganum harmala and its main alkaloids. Pharamagcon Rev, 7(14):199 – 212.
[16]- Nath, D. and Sethi, N. 1993. Study on teratogenic and antifertility activity of Peganum harmala in rats. Fitoterapia LXIV, (4) : 321 - 324.
[17]- Pulpati, H,; Biradar. Y. S. and Rajani, M. 2008. High- performance thin chromatography densitometric method for the guantification of harmine, harmaline, vasicine and vasicinone in Peganum harmala. JAOAC Int. 91(5): 1179-85.
[18]- Sobhani, A. M.; Ebrahimi, S. A. and Mahmoudian, M. 2002. An Invitro evaluation of human DNA topoisomerase I inhibition by Peganum harmala seeds extract and its beta-carbolines Alkaloids. J. Pharm. Sci., 5 (1): 19 – 23.
Authors
This work is licensed under a Creative Commons Attribution 4.0 International License.
In a brief statement, the rights relate to the publication and distribution of research published in the journal of the University of Sebha where authors who have published their articles in the journal of the university of Sebha should how they can use or distribute their articles. They reserve all their rights to the published works, such as (but not limited to) the following rights:
- Copyright and other property rights related to the article, such as patent rights.
- Research published in the journal of the University of Sebha and used in its future works, including lectures and books, the right to reproduce articles for their own purposes, and the right to self-archive their articles.
- The right to enter a separate article, or for a non-exclusive distribution of their article with an acknowledgment of its initial publication in the journal of Sebha University.
Privacy Statement The names and e-mail addresses entered on the Sabha University Journal site will be used for the aforementioned purposes only and for which they were used.