Vascular Calcification: Role of Vascular Smooth Muscle Cells and Its Regulation by MicroRNA
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Calcification, MicroRNA, Muscle Cells, Vascular Smooth
Abstract
In this review, the aim is to discuss the pathological development of vascular calcification, including a brief description of arterial wall structure and function and the development of atherosclerosis, highlighting normal physiological and vascular calcification with particular emphasis on their common characteristics, and critically review the recent findings implicating the role of vascular smooth muscle cells in the pathogenesis of the calcification process including the role of microRNAs in regulation of these cells' phenotype as a target to control cardiovascular calcification.
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