The Evaluation of Bupivacaine-Clonidine Combination Effect Intrathecally for Postoperative Analgesia and Motor Block in Caesarean Section Patient

Abdulmutaleb B. Issa; Masoud A. Elfeituri; Ahmed M. Gellai

Authors

Abdulmutaleb B. Issa Department of Anaesthesia, Tripoli Medical Center, Tripoli, Libya
Masoud A. Elfeituri Department of Anaesthesia, Faculty of Medicine, University of Benghazi, Benghazi, Libya
Ahmed M. Gellai Department of Anaesthesia, Faculty of Medicine, University of Benghazi, Benghazi, Libya

Keywords:

Obstetric, Caesarean section, Spinal anaesthesia, Postoperative pain, Bupivacaine, Clonidine, Fentanyl

Abstract

Background: During the last two decades, alpha-2 agonists such as clonidine have been used neuroaxially as LA adjuncts to improve and prolong the quality of postoperative analgesia in caesarean section patient.

Objective: the aim of this prospective observational study was to assess the effectiveness of administration of clonidine in combination with heavy bupivacaine intrathecally in management of postoperative pain in caesarean section patients.

Methods: In this prospective, randomized single-blinded study after obtaining their informed consent, 68 patients, undergoing caesarean section under spinal anaesthesia, grouped in two groups, 36 pregnant women received intrathecally combination of 2 ml heavy bupivacaine with 50 µg clonidine in 0.5 ml normal saline, using 10 scaled VAS for assessment postoperative pain and bromage score for motor block.

Results: there was a clear difference between the two groups, the duration of sensory block; motor block and analgesia were greatest in first group who received heavy bupivacaine-clonidine combination in comparison with other group that received bupivacaine-fentanyl.

Conclusions: Administration of clonidine to LA intrathecally in caesarean section patient improved the quality of intraoperative sensory block and prolongs the postoperative sensory block, motor block and analgesia.

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