Comparative effect of aqueous extract Abelmoschus Esculentus with metformin on female diabetic rats

Aisha Idriss Abdullah Idriss (1) , Ibrahim Azaga (2) , Fatima Abdullaha (3)
(1) Zoology Department, Faculty of Science, Sebha University, Libya ,
(2) Zoology Department, Faculty of Science, Sebha University, Libya ,
(3) Department of Animal Production, Faculty of Agricultural Sebha University, Libya

Abstract

In spite of the existed new of medical drugs the help to control diabetes there is not a treatment that gives complete recovery thus ,researchers  turned  to treatment  with naturel extracts given their important contents of active substances and high biological effectiveness, the aim of this researchers is to make a comparison between  the effect of the aqueous extract of  the Abelmoschus esculentus and  metformin on diabetic female rats ,In this study, 35 female albino rats, divided into seven groups were used after Induced streptozotocin to infect them with diabetes at dose 25mg/kg, , after being infected, the animals received therapeutic concentrations of 500 mg, 1000 mg form each of the plant extract and metformin  for a period of 30 days, the results showed that as treatment with metformin, showed a significant decrease in blood glucose level in the high concentration group, it was (357.24±75.41) compared to The infected group (471.99±88.66) at the level of significance (p<0.05) and the result of treatment with the extract with a high concentration was (223.93±75.41) and low (102.22±79.91) there was a significant decrease at the level of significance (p<0.05) in the level of blood glucose compared to the group On the other hand, the extract led to a significant increase in body weight (P<0.05) in the high concentration group (220.97±45.92) compared to metformin, which contributed to a significant decrease in weight in the high concentration group (173.00±9.85) when significant (P< 0.05)., and the synergy group showed a non-significant decrease in the level of blood glucose (101.824±87.88) compared to the extract and metformin groups. It is equal to the high concentration group of metformin.

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Authors

Aisha Idriss Abdullah Idriss
AE.SALIM@Sebhau.edu.ly (Primary Contact)
Ibrahim Azaga
Fatima Abdullaha
Idriss ع., Azaga إ., & Abdullaha ف. (2024). Comparative effect of aqueous extract Abelmoschus Esculentus with metformin on female diabetic rats. Journal of Pure & Applied Sciences, 23(1), 96–101. https://doi.org/10.51984/jopas.v23i1.2389

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