Comparative effect of aqueous extract Abelmoschus Esculentus with metformin on female diabetic rats
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diabetic, type 2, Abelmoschus esculentus, metformin, Synergy
Abstract
In spite of the existed new of medical drugs the help to control diabetes there is not a treatment that gives complete recovery thus ,researchers turned to treatment with naturel extracts given their important contents of active substances and high biological effectiveness, the aim of this researchers is to make a comparison between the effect of the aqueous extract of the Abelmoschus esculentus and metformin on diabetic female rats ,In this study, 35 female albino rats, divided into seven groups were used after Induced streptozotocin to infect them with diabetes at dose 25mg/kg, , after being infected, the animals received therapeutic concentrations of 500 mg, 1000 mg form each of the plant extract and metformin for a period of 30 days, the results showed that as treatment with metformin, showed a significant decrease in blood glucose level in the high concentration group, it was (357.24±75.41) compared to The infected group (471.99±88.66) at the level of significance (p<0.05) and the result of treatment with the extract with a high concentration was (223.93±75.41) and low (102.22±79.91) there was a significant decrease at the level of significance (p<0.05) in the level of blood glucose compared to the group On the other hand, the extract led to a significant increase in body weight (P<0.05) in the high concentration group (220.97±45.92) compared to metformin, which contributed to a significant decrease in weight in the high concentration group (173.00±9.85) when significant (P< 0.05)., and the synergy group showed a non-significant decrease in the level of blood glucose (101.824±87.88) compared to the extract and metformin groups. It is equal to the high concentration group of metformin.
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References
- Forouhi, N.G. and N.J.J.M. Wareham. 2010, Epidemiology of diabetes.. 38(11): p. 602-606. DOI: https://doi.org/10.1016/j.mpmed.2010.08.007
- الرحـــيم, ب.س.ع., 2012 النشــاطات المضـادة للأكسدة والمثبطة للإنزيم المؤكسد للكزانثين لمستخلصات أوراق Hertia cheirifolia L., Université de Sétif 1-Ferhat Abbas.
- Goyal, R. and I. Jialal, Diabetes mellitus type 2. 2018.
- Labban, L.J.I.J.P.B.S. 2014, Medicinal and pharmacological properties of Turmeric (Curcuma longa): A review.. 5(1): p. 17-23.
- Verma, S., Gupta, M., Popli, H. & Aggarwal, G. J. I. J. O. P. 2018. Diabetes mellitus treatment using herbal drugs. 10(1): p. 1-10. DOI: https://doi.org/10.5138/09750185.2181
- Gemede, H.F., Ratta, N., Haki, G. D., Woldegiorgis, A. Z. & Beyene, F. J. J. F. P. T. 2015. Nutritional quality and health benefits of okra (Abelmoschus esculentus): A review.. 6(458): p. 2. DOI: https://doi.org/10.4172/2157-7110.1000458
- Zhu, X.-m., 2020, Structural properties, bioactivities, and applications of polysaccharides from Okra [Abelmoschus esculentus (L.) Moench]: A review.. 68(48): p. 14091-14103. DOI: https://doi.org/10.1021/acs.jafc.0c04475
- Islam, M.T.J.P.r. 2019, Phytochemical information and pharmacological activities of Okra (Abelmoschus esculentus): A literature‐based review.. 33(1): p. 72-80. DOI: https://doi.org/10.1002/ptr.6212
- Uddin Zim, A. 2019, Effect of okra (Abelmoschus esculentus) mucilage on glucose level and lipid profile of alloxan-induced diabetic mice., A thesis submitted in the partial fulfillment of the requirements for the ….
- Dubey, P. and S.J.J.M.P.S. Mishra 2017, A review on: Diabetes and okra (Abelmoschus esculentus).. 5(3): p. 23-26.
- Sabitha, V., Ramachandran, S., Nnven, K., Panneerselvam, K. J. J. O. P. & Sciences, B. 2011. Antidiabetic and antihyperlipidemic potential of Abelmoschus esculentus (L.) Moench. in streptozotocin-induced diabetic rats.. 3(3): p. 397. DOI: https://doi.org/10.4103/0975-7406.84447
- Karunakaran, U., ElumalaiL, S., Moon, J. S., Jeon, J.-H., Kim, N. D., Park, K.-G., Won K. C., Leem, J., Lee, I.-K. J. D. & Journal, M. 2019. Myricetin protects against high glucose-induced β-cell apoptosis by attenuating endoplasmic reticulum stress via inactivation of cyclin-dependent kinase 5.. 43(2): p. 192-205. DOI: https://doi.org/10.4093/dmj.2018.0052
- Pandey, K.B., N. Mishra, and S.I.J.Z.f.N.C. Rizvi, 2009 Myricetin may provide protection against oxidative stress in type 2 diabetic erythrocytes.. 64(9-10): p. 626-630. DOI: https://doi.org/10.1515/znc-2009-9-1004
- Ramachandran, S., Sandeep, V. S., Srinivas, N. K., Dhanararaju, M. J. R. & Biosciences, R. I. 2010. Anti-diabetic activity of Abelmoschus esculentus Linn on alloxan-induced diabetic rats.. 4,121-123.
- Jain, P. and R. Jain. 2019, Antidiabetic potential of Abelmoschus Esculentus Linn. in alloxan-induced diabetic rat..
- Gemede, H.F., Haki, G. D., Beyene, F., Rakshit, S. K., Woldegiorgis, A. Z. J. F. S. & Nutrition 2018. Indigenous Ethiopian okra (Abelmoschus esculentus) mucilage: A novel ingredient with functional and antioxidant properties. 6(3): p. 563-571. DOI: https://doi.org/10.1002/fsn3.596
- Szkudelski, T.J.P.r. 2001, The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.. 50(6): p. 537-546.
- Brosius, F., 2019. Low-Dose Streptozotocin Induction Protocol (mouse) V. 2019. DOI: https://doi.org/10.17504/protocols.io.3angide
- Lenzen, S.J.D. 2008, The mechanisms of alloxan-and streptozotocin-induced diabetes.. 51(2): p. 216-226. DOI: https://doi.org/10.1007/s00125-007-0886-7
- Kennedy, M.S.N. and U.J.B.C.P.a.L.M.B.t.e.M.-H.E. Masharani. 2018, Pancreatic hormones & antidiabetic drugs.: p. 747-771.
- He, L. and F.E.J.C.m. Wondisford. 2015, Metformin action: concentrations matter. 21(2): p. 159-162. DOI: https://doi.org/10.1016/j.cmet.2015.01.003
- Hundal, R.S., Krssak, M., Dufour, S., Laurent, D., Lebon, V., Chandramouli, V., Inzucchi, S. E., Schumann, W. C., Petersen,
- metformin reduces glucose production in type 2 diabetes.. 49(12): p. 2063-2069. DOI: https://doi.org/10.2337/diabetes.49.12.2063
- Sato, M., Murakami, K., UNO, M., Nakagawa, Y., Katayama, S., Akagi, K.-I., Masuda, Y., Takegoshi, K. & IRIE, K. J. J. O. B. C. 2013. Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.. 288(32): p. 23212-23224. DOI: https://doi.org/10.1074/jbc.M113.464222
- Aditama, A.P.R.J.F.J.F.d.I.K. 2019, Antidiabetic activities of 96% ethanol extract of Abelmoschus esculentus on Balb-C mice strain. 4(2): p. 21-25. DOI: https://doi.org/10.22219/farmasains.v4i2.10718
- Perez, J., Baritua, R. J., Pacalna, M. O. & Malayao, S. J. I. 2013. Exploratory investigation on the hypoglycemic effect of Abelmoschus esculentus in mice. 2: p. 250-3.
- Subrahmanyam, G., Sushma, M., Alekya, A., Neeraja, C., Harsha, H. S. S. & Ravindra, J. J. I. J. R. P. C. 2011. Antidiabetic activity of Abelmoschus esculentus fruit extract. 2011. 1: p. 17-20.
- Aba, P.E. and I.U. Asuzu. 2018, Mechanisms of actions of some bioactive anti-diabetic principles from phytochemicals of medicinal plants: A review..
- Shiming, Z., Mak, K.-K., Balijepalli, M. K., Chakravarthi, S., Pichlka, M. R. J. B. & Pharmacotherapy 2021. Swietenine potentiates the antihyperglycemic and antioxidant activity of Metformin in Streptozotocin induced diabetic rats. 139: p. 111576. DOI: https://doi.org/10.1016/j.biopha.2021.111576
- Badrie, N. 2016, Nutrient profile, bioactive components, and functional properties of okra (Abelmoschus esculentus (L.) Moench.: p. 365-409. DOI: https://doi.org/10.1016/B978-0-12-802972-5.00018-4
- Khatun, H., Rahman, A., Biswas, M. & Islam, A. U. J. I. S. R. N. 2011 Water-soluble fraction of Abelmoschus esculentus L interacts with glucose and metformin hydrochloride and alters their absorption kinetics after coadministration in rats. DOI: https://doi.org/10.5402/2011/260537
- Dugani, A.M., Alkhetally, W. I., Elghedafi, E. O. & Alkayed, F. W. J. L. I. M. U. J. 2018. Effects of the aqueous extract from Abelmoschus esculentus L peel on hyperglycemia and hyperlipidemia induced by dexamethasone in rats.. 3(1): p. 3. DOI: https://doi.org/10.4103/LIUJ.LIUJ_1_17
- Herowati, R.J.I.J.o.P. 2020. Antidiabetic activity of okra fruit (Abelmoschus esculentus (L) Moench) extract and fractions in two conditions of diabetic rats. 31(1): p. 27. DOI: https://doi.org/10.14499/indonesianjpharm31iss1pp27
- العيسى, أحمد بن محمد(2004). تأثير ستربتوزوتوسين كمحدثات للسكري طراز- 1 التجريبي في الجرذان البيضاء, رسالة ماجستير ,كلية العلوم ,المملكة العربية السعودية/جامعة الملك سعود .
- السامرائي ,يوسف شكوري ياسين (2017).دراسة كيموحيويه ونسيجية للتأثير الفموي المخفض للسكري (الميتفورمين) عل بعض مضادات الأكسدة في الارانب المصابة بالسكري المستحدثة بالألوكسان. مجلة علوم المستنصرية.(28).
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