The effect of metformin use on vitamin B12 level in patients with type 2 diabetes mellitus in Brack
Abstract
Background: - Metformin, a first-line treatment for type 2 diabetes (T2DM), is associated with malabsorption of vitamin B12, and therefore vitamin B12 deficiency or insufficiency can lead to serious complications such as neuropathy or anemia in the future. T2DM is the most common type of diabetes and is characterized by hyperglycemia, insulin resistance, and relative insulin deficiency.
Objective: - The current study aimed to study the effect of metformin treatment on some blood values and vitamin B12 in type 2 diabetic patients.
Methods: - Our study included 81 women with T2DM, ages 33 to 66. The women were divided into two groups: women taking metformin (n = 51) and women taking antidiabetic drugs (the control group) (n = 30).
Data were collected using questionnaires and laboratory analyses of blood samples. The samples were tested for complete blood count, vitamin B12 measurement, and glucose assay.
Results: - The results of our study showed that there were significant differences in mean RBCs and hemoglobin between the metformin group and the control group, but there were no statistically significant differences in PCV, MCV, MCH, and MCHC between the two groups. The mean vitamin B12 concentration (571.61 ± 171.59 pg/mL) was significantly lower in the metformin group compared to the control group (693.93 ± 106.71 pg/mL) (p < 0.05). No correlation was shown between the duration of metformin use in years and vitamin B12 levels in serum (r = -0.114, p = 0.424); there was no correlation between metformin dose use and serum vitamin B12 (r = -0.056, p = 0.699). We conclude from this study that metformin plays a role in vitamin B12 deficiency in women with type 2 diabetes.
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