Synthesis and Antibacterial Activity of Aromatic Diacetates
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Aromatic Diacetates, Antibacterial Activity, Antibiotic Resistance, Minimum Inhibitory Concentration, Minimum Bactericidal Concentration
Abstract
The need to discover new generation of antibiotics with novel mechanism of action has continued to be of paramount importance due to the growing cases of resistant strains of bacterial species. In this work, some known aromatic diacetates were synthesised and characterised using NMR and FTIR spectroscopic techniques. The obtained compounds were subjected to in vitro susceptibility test using a disc diffusion method, and the minimum inhibitory concentration (MIC) of the compounds was also evaluated. Further testing for minimum bactericidal concentration (MBC) for the active compounds was also carried out. The susceptibility test recorded in comparison with a standard drug (ciprofloxacin) showed that all the compounds exhibited high activities against the organisms at 1,000 µg/ml except compound 2d which had no activity on Bacillus megaterium. The highest zone of inhibition of Staphylococcus aureus, Bacillus subtilitis, Bacillus megaterium, Pseudomonas aeruginosa, Escherichia coli, and Salmonella typhimurium were found to be 34 mm, 24 mm, 25 mm, 36 mm, 28 mm, 36 mm respectively. While, the lowest MIC and MBC values of 15 µg/ml were found for some of the compounds against some of the bacterial species.
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