Study of some liver function tests in patients with breast carcinoma during chemotherapy treatment at oncology center in sebha city
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breast carcinoma, liver, Chemotherapy, enzyme, serum
Abstract
Breast carcinoma is the most common invasive carcinoma in all women worldwide, and it is also the leading cause of women dying in developing countries. This study aims to evaluate the effect of chemotherapy treatment effect on liver function tests in Libyan breast carcinoma patients. In this study, 40 cases of which 30 are in various stages of breast carcinoma (28 female and 2 male) and the rest without carcinoma (group control) were selected from Oncology Centre in Sebha city. Liver function tests including; total bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) activities were performed using the spectrophotometric technique. The cases were grouped according to their age (30 to 70 years, with an average age of 50 to 40 years). The mean values of AST, ALT, alkaline phosphatase and total bilirubin in breast carcinoma patients during chemotherapy treatment were 32.1 ± 13.6 U/L, 11.9 ±7.21 U/L, 631 ± 54.3 U/L, 2.34 ± 1.73 mg/dl, respectively. These values were compared with those for group control, and no significant statically differences observed. In conclusion, the present study suggested that liver function tests of breast carcinoma patients during their chemotherapy treatment might be not an acceptable biochemical parameter for diagnosis and monitoring breast carcinoma.
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